dear sir,

i would like to know what is free energy importance here in ligand binding. why it is said that more negative free energy strong inhibition . in some research paper it was quoted that -7.43 around free energy is good for drug , what is this

tell me range of frequency for a strong interacting ligand to be a nest drug

thanks in advance

I would to like the same, if you have resolved this issue. Let me know, please.